Coumarins and derivatives
TARGETMOL CHEMICALS INC 7-ACETOXY-4-METHYLCOUMAR 25MG
Also available in 5 mg 10 mg 50 mg 100 mg 200 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. 7-Acetoxy-4-methylcoumarin is a fluorogenic substrate for carboxylesterase yielding a blue fluorescent solution upon cleavage. The compound has been used in aprotic media a cell membrane environmental mimic to study superoxide and related oxyl-radical reactions of model biological membranes dispersed in aqueous media. Due to the ability for AchE to cleave and activate 7-Acetoxy-4-methylcoumarin the fluorogenic substrate has been used to study the AchE inhibitor Tacrine·HCl (sc-200172). The compound has also been isolated from Trigonella foenum graceum. purity: 88%
Medchemexpress LLC Coumarin 106 | 41175-45-5 | MFCD00041949 | >98.0% | 281.35 | C18H19NO2 | 50 MG
Coumarin 106 is a dipolar laser dye used in research that also functions as a cholinesterase inhibitor. It exhibits mixed-type inhibition of acetylcholinesterase (reported pIC50 4.97, Ki 2.36 μM) and lower potency against butyrylcholinesterase (pIC50 4.56). Molecular formula C18H19NO2 and molecular weight 281.35. In vitro data report no toxicity in Caco-2 cells.
- Dipolar laser dye useful for fluorescence and photonic applications.
- Inhibits acetylcholinesterase with reported pIC50 4.97 and Ki 2.36 μM.
- Also inhibits butyrylcholinesterase with pIC50 4.56.
- Molecular weight 281.35 and formula C18H19NO2.
- Reported non-toxic in Caco-2 cell assays.
- Supplied as a 50 mg research reagent.
Cayman Chemical 3-Cyno-7-ethoxycoumarIn 25mg
A fluorogenic CYP450 substrate; a substrate for CYP1A1 and CYP1A2; metabolized to a lesser extent by CYP2D6 and CYP2C19; metabolized to 3-cyano-7-hydroxycoumarin and its fluorescence can be used to quantify CYP450 isoform activity
Medchemexpress LLC 6-Methylcoumarin | 92-48-8 | 160.17 | 1 ML
6-Methylcoumarin is a synthetic fragrance primarily used in cosmetics. It has been reported to be almost nonphototoxic in epidermal tissue and cell culture phototoxicity test models. Studies show that when HaCaT cells are treated with 6-Methylcoumarin and UVA irradiation, it produces γ-H2AX-positive cells at concentrations from 100 nM.
- Synthetic fragrance widely used in cosmetics.
- Reported to be almost nonphototoxic in epidermal tissue and cell culture phototoxicity test models.
Medchemexpress LLC 7-Methylcoumarin | 2445-83-2 | 50 G
7-Methylcoumarin is a coumarin derivative with potent hepatoprotective and antioxidant properties. It acts as a mechanism-based inhibitor for CYP2A6. This compound has been shown to significantly decrease alanine aminotransferase (ALT), aspartate aminotransferase (AST), and serum bilirubin (TB) in rats with CCl4-induced liver damage, while also restoring total protein (TP) and albumin (TA) levels in serum and preventing oxidative stress. Additionally, 7-Methylcoumarin can reduce the mitotic activity of *A. sativum* promeristem.
- Potent hepatoprotective properties.
- Antioxidant properties.
- Mechanism-based inhibitor for CYP2A6.
- Decreases ALT, AST, and serum bilirubin in rats with CCl4-induced liver damage.
- Restores total protein and albumin levels in serum.
- Prevents oxidative stress.
- Can decline mitotic activity of *A. sativum* promeristem.
Apexbio Technology LLC 3-Nitrocoumarin 28448-04-6 10mg
3-Nitrocoumarin (CAS 28448-04-6) is a selective inhibitor of phospholipase C- (PLC- ) an enzyme involved in cellular signal transduction through the hydrolysis of membrane phospholipids and subsequent generation of secondary messengers By suppressing PLC- catalytic activity 3-Nitrocoumarin disrupts related intracellular signaling pathways thereby enabling investigation of PLC- -mediated mechanisms in various physiological and pathological contexts This compound is widely utilized in studies focused on elucidating the roles of PLC- in disease models and fundamental biomedical research
Medchemexpress LLC My-1076 | 3008262-76-5 | MFCD35444266 | 99.1% | 539.57 g·mol-1 | C29H33NO9 | 10 MG
MY-1076 is a small-molecule inhibitor of Yes-associated protein (YAP) used for laboratory research. It induces YAP degradation and apoptosis and shows potent antiproliferative activity against several cancer cell lines with low-nanomolar IC50s. Reported properties include CAS 3008262-76-5, formula C29H33NO9, molecular weight 539.57 g·mol-1, and high reported purity.
- Induces YAP degradation and apoptosis in vitro
- Potent antiproliferative activity with low-nanomolar IC50s
- High purity suitable for analytical and biological studies
- Available in multiple small-scale quantities for research use
- Intended for research use only; not for human or clinical use
Medchemexpress LLC 7-Hydroxycoumarin-4-acetic acid | 6950-82-9 | 500 MG
7-Hydroxycoumarin-4-acetic acid is a pH-indicator dye that covalently binds to bovine serum albumin (BSA) at the positions of reactive amino groups, with a λmax of 326 nm.
- pH-indicator dye.
- Covalently binds to bovine serum albumin (BSA).
- λmax = 326 nm.
- For research use only.
Medchemexpress LLC 7-hydroxycoumarin-3-carboxylic acid N-succinimidyl ester | 134471-24-2 | 100 MG
7-Hydroxycoumarin-3-carboxylic acid N-succinimidyl ester is the amine-reactive succinimidyl ester of 7-Hydroxycoumarin-3-carboxylic acid. It functions as a blue fluorescent dye for labeling proteins and nucleic acids.
- Amine-reactive succinimidyl ester
- Blue fluorescent dye
- Used for labeling proteins
- Used for labeling nucleic acids
Medchemexpress LLC 7-Ethoxy-4-methylcoumarin | 87-05-8 | 99.44% | 100 G
7-Ethoxy-4-methylcoumarin is a coumarin derivative that functions as a substrate probe for mammalian cytochromes P450 1A1, 2B4, and 2B6.
- Coumarin derivative
- Substrate probe
- Targets mammalian cytochromes P450 1A1, 2B4, and 2B6
Indofine Chemical Linarin With Hplc, 5 Mg
LINARIN with HPLC, Flavonoid & Coumarins, 480-36-4, 98.5% by HPLC, 5 mg